2cp bad trip

Addiction Treatment in New Jersey

GUIDE TO 2C-P AND THE POTENTIAL DANGERS (IS IT ADDICTIVE?)

Medically Reviewed

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What Is 2-CP?

• The Positive Effects
• The Potential Dangers
• How Does MDMA Relate

Is 2C-P Deadly?

• Why Professional Treatment?

When a 24-year-old woman took 2C-P at a concert in the United Kingdom in 2017, she experienced a “bad trip.” A report indicated that after taking the potent psychedelic, she screeched like an animal, scraped thorns across her face and ate twigs. According to the Guardian , She died an hour before her 25th birthday. 

While smaller amounts of ecstasy (MDMA) and ketamine were found in her system, she was believed to be the first person in the world to die from 2C-P. 

While it is regarded as a lesser-known drug of the phenethylamine class, 2C-P is a powerful, enduring stimulant and hallucinogenic, capable of producing dangerous effects. There isn’t much research on this controversial, enigmatic substance, which belongs to a family of designer drugs known for its stimulant and hallucinogenic effects.

It’s worth noting that in 2012, 2C-P and other drugs of its kind were classified as Schedule I controlled substances by the Drug Enforcement Administration (DEA), thanks to the U.S. Food and Drug Administration Safety and Innovation Act . The Schedule I designation indicates that 2C-P has no accepted medical use and carries a high potential for abuse.   

In other words, it can produce addiction.  

Plus, the little information that is available regarding 2-CP indicates that it can produce a range of effects, many of which can be dangerous, if not life-threatening.  

The drug known as 2-CP was developed to mimic the euphoric effects of substances such as MDMA and lysergic acid diethylamide (LSD). It is a part of a family of designer drugs that are of the phenethylamine class. The “2C” designation was an acronym invented by Alexander Shulgin, who synthesized these 2C substances in around 1974. Shulgin is widely known for popularizing the use of MDMA. 

The most common form of 2-CP is as a hydrochloride salt, which usually resembles a white powder or white crystals.  

While Shulgin was a proponent of using MDMA and 2C drugs for therapeutic purposes, they gained popularity as “club drugs.”  

Each drug in the 2C family, whether that is 2C-I, 2C-B, and 2C-P, each has its own, unique chemical properties. What differentiates 2C-P from the others is the exceptional duration of its effects. Its lasting effects are what makes 2C-P addictive and highly dangerous. 

The Positive Effects of 2C-P

One report indicates that the hallucinogenic, psychedelic, and entheogenic effects peak at three to five hours when the drug is ingested, yet this peak lasts between five to 10 hours. What’s more, the overall 2C-P effects can last up to 20 hours. One report indicated that a 2C-P high could last for up to 24 hours.  

Whatever the case, users report that 2C-P can make users experience open eye and closed-eye visualizations. The drug gives users an effect that is similar to MDMA but with heightened psychedelic visual effects and sensations. 

Shulgin suggested that the intended dosage range for 2C-P should be between 6 to 10 milligrams (mg) in a book he co-authored with his wife named PiHKAL: A Chemical Love Story (PiHKal stands for Phenethylamines I Have Known and Loved).  

An online database that documents the effects of psychoactive substances on humans indicates that 2C-P is capable of producing a range of effects from positive to negative. 

When the drug is ingested at the range Shulgin suggests, the positive effects from 2C-P include the following, according to Erowid.org :

• Mental and physical stimulation
• Sensory enhancement
• Increased mental clarity
• Brightened colors, enhanced visual perception
• Introspection and philosophical insights
• Enhanced mood, euphoria
• Enhanced tactile sensation
• Increased giggling and laughing
• Feelings of empathy
• Increased sociability at moderate doses
• Increased sense of creativity / artistic inspiration

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The Potential Dangers of 2C-P

However, Shulgin also reported experiencing negative effects from 2C-P when he took a single 16 mg dose. It caused him to describe the event as “a physical disaster, not to be repeated.”  

A forensic pathologist who testified in the case of the 24-year-old woman who died from 2C-P shed light on its negative effects. In addition to eliciting potent hallucinations, 2C-P can also cause agitation, an abnormally rapid heartbeat, and increased body temperature and blood pressure — effects endemic of a stimulant.

In addition to a host of neutral effects that come from use, such as a change in consciousness, open and closed-eye visuals, confusion, out-of-body experiences, restlessness, and auditory hallucinations, it can produce a litany of negative effects at higher doses, which include: 

• Stomach discomfort such as nausea, vomiting, gas
• Muscle spasms, jaw clenching
• Muscle fatigue, pain
• Motor impairment
• Nasal discomfort, nasal drip when the drug is snorted
• Anxiety, fear, or paranoia
• Severe mental confusion
• Disturbing hallucination, mental visions
• Severely uncomfortable stimulation (mental and physical)
• Intense or overwhelming visual disturbances
• Significantly elevated heart rate
• Sweating, chills, flushing
• Difficulty speaking
• Vasoconstriction, increased blood pressure

The Effects of MDMA and Why It Relates to 2C-P

Not much is known about the true dangers of the 2C family of drugs, including its toxicity. The reason? When Shulgin developed 2Cs, there were no major investigations on the uses and adverse effects of these substances outside of his own experiments. There is not even a hint as to whether these drugs possess therapeutic effects.

The drug that is closest to 2C-P in terms of its effects and composition is MDMA. 

The symptoms of intoxication and withdrawal that result from MDMA might be instructive in terms of what 2C drugs are capable of producing. 

Those MDMA Symptoms Can Occur In Three Stages and Include:

• Heightened senses
• Hallucinations, especially tactile sensations
• Feeling good
• Heightened empathy
• Emotional warmth
• Anxiety or paranoia
• Mental and physical relaxation
• Increased energy
• Restlessness

The Short-Term Physical Effects, Which Can Be Damaging, Include:

• Muscle tension
• Teeth grinding or jaw clenching
• Nausea and vomiting
• Heat exhaustion
• Rapid heartbeat
• High blood pressure
• Faster, shallower breathing
• Feeling faint
• Sweating and becoming dehydrated
• Chills, like having the flu
• Blurry or double vision
• Impulsiveness

Once the Effects of Mdma Wear Off, You Will Experience Comedown Symptoms. Among Those Are:

• Sleep disturbances
• Cravings for the drug
• Memory loss

2C-P may not be deadly, but anecdotal evidence suggests that it can produce life-threatening overdose symptoms. For example, seven teens overdosed on 2C-P at a concert in Connecticut in 2013. 

According to a television report from a station in the area, “The concert, called “Adventure Land” began without incident but at around 10:30 p.m., four teenagers dropped to the ground almost simultaneously.” 

First responders performed CPR or used a defibrillator to revive the victims.  

What’s more, one study concluded that in lethal 2C drug cases, users exhibited “a syndrome consistent with excited delirium including severe agitation, aggression, violence, seizures, and hyperthermia.” 

Also, the dangers associated with MDMA also suggest that 2C drugs like 2C-P can be life-threatening, particularly when they are mixed with other intoxicants. 

With MDMA, The Life-Threatening Effects Can Include:

• Heat stroke
• Confusion or delirium
• Aggressiveness
• Strong, rapid pulse
• No sweat even though the skin is very hot
• Dry, flushed skin
• Feeling or appearing faint

Why Professional Treatment Is Necessary

While not much is known about 2C-P, there is enough anecdotal evidence to suggest that it can be habit-forming, dangerous, and life-threatening as the effects it produces inculcates addiction.

Another unknown factor is the level of toxicity it can pose to the body. These factors indicate that professional treatment is vital to break you free from 2C-P addiction and the harrowing effects it can unleash. 

This is especially the case if 2C-P is being abused with alcohol , stimulants , or opioids , as your life is at stake. 

By enrolling in a professional recovery program, you can access comprehensive, specialized treatment backed by evidence. The initial stage of this medically and clinically supervised process is acute treatment , where the 2C-P and other toxins are removed from your body. 

In acute treatment, you will be monitored by doctors, nurses, and other medical staff around the clock. Should any medical issues or painful withdrawal symptoms arise, they will be on hand to address them. 

After this acute treatment period, you will be enrolled in clinical stabilization services or partial care where you will receive therapy through an array of services, which include: 

Holistic Treatments

• Acupuncture/acupressure
• Nutritional assessments

Group Therapy

• Emotional regulation
• Medical education
• Motivational enhancement
• Relapse prevention
• The 12 steps of recovery
• Wellness skills

Individual Therapy

• Cognitive behavioral therapy (CBT)
• Dialectical behavior therapy (DBT) skills
• Genetic testing
• Family-focused therapy
• Trauma-informed sessions

Additionally, after your treatment period ends, a caseworker will connect you to a supportive recovery community that can help you avoid relapse.

Get Help Today

You do not have to struggle with the devastating effects of 2C-P. Professional treatment can help free you from abuse, addiction, and the life-threatening consequences that come from use. 

Call 855-956-4940 anytime, day or evening, for a free consultation with one of our knowledgeable addiction recovery specialists. They can help you locate the right treatment option. C ontact us online for more information. 

At Delphi Behavioral Health Group we take pride in providing accurate and up-to-date content to all our website users.

Written by: Tacuma Roeback

About Tacuma Roeback: Tacuma is a writer for California Highlands and has dedicated her career to creating well-researched content so that those that are in search of treatment can find the help they need.

• (n.d.). Retrieved from https://erowid.org/chemicals/2cp/2cp_effects.shtml
• (n.d.). Retrieved from https://www.erowid.org/library/books_online/pihkal/pihkal036.shtml
• (2015, July 15). All ‘Smiles’: The history of the 2C designer drug class. Retrieved from https://www.theverge.com/2015/7/15/8962743/all-smiles-the-history-of-the-2c-designer-drug-class
• (2019, February 15). Ecstasy Abuse & Addiction What are the Signs & Symptoms. Retrieved from https://delphihealthgroup.com/ecstasy/
• (2019, February 13). Bestival death may be world’s first 2C-P fatality, court hears. Retrieved from https://www.theguardian.com/uk-news/2019/feb/13/bestival-death-may-be-worlds-first-2-cp-fatality-court-hears
• (2019, February 05). Party drugs killed TV actor’s daughter at music festival, court hears. Retrieved from https://www.theguardian.com/uk-news/2019/feb/05/louella-fletcher-michie-death-bestival-overdose-trial

2C-B: Effects, Dosage, & Safety

The middle ground between MDMA & LSD. 

Trip Sitter Safe 2C-B Guidelines

What’s the dose of 2c-b, what does 2c-b feel like, does 2c-b have medical value, can 2c-b cause a bad trip, does 2c-b cause a hangover, how long does 2c-b last, how is 2c-b used, other members of the 2c- family, 2c-b vs. lsd, 2c-b vs. mescaline, 2c-b vs. mdma, 2c-b adulteration, 2c-b & drug interactions, 2c-b side-effects, is 2c-b addictive, is 2c-b legal, how 2c-b works, 1. how do i test the purity of 2c-b, 2. will 2c-b show up on a drug test, 3. is 2c-b dangerous, 4. can i microdose 2c-b, subscribe to get a weekly dose of psychedelics in your inbox.

Everybody has heard of MDMA (ecstasy) and LSD (lysergic acid diethylamide) — they’ve become staples in the world of mind-altering substances.

But there’s another popular psychoactive substance that’s been residing in the shadows since the 1980s. This substance is called 2C-B.

The effects of 2C-B are often described as being a mid-point between the empathogenic effects of MDMA and the hallucinogenic effects of LSD.

So what exactly is 2CB? Is it safe?

In this article, we’ll cover everything you need to know about 2C-B — including how it works, what it feels like, and how to use it safely.

What is 2C-B?

2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a synthetic psychedelic substance derived from mescaline. It was invented in 1974 by a man named Alexander Shulgin — the godfather of MDMA and creator of the entire 2C- family of substances.

Shulgin invented well over 200 psychoactive compounds in his research lab dubbed “The Farm.”

Shulgin considered 2C-B to be one of his greatest creations. In one of his books — PiHKAL (phenethylamines I Have Known And Loved) — he listed 2C-B among his “magic half dozen”.

The other five include mescaline, DOM, 2C-E, 2C-I, 2C-T2 , and 2C-T7 .

The effects of 2C-B have been described as a combination between LSD and MDMA — but this is a simplification. In reality, the 2C-B experience is entirely unique.

The qualities of 2C-B made it popular as a sex-enhancement drug in the 80s. The German pharmaceutical company Drittewelle started producing the drug under the name “Nexus.” It was sold in sex shops as a way to boost libido, sexual connection and increase stamina and energy. 2C-B is still considered by many to be the best psychedelic to use during sex of all time.

In Shulgin’s own words , “[2C-B] is, in my opinion, one of the most graceful, erotic, sensual, introspective compounds I have ever invented.”

2C-B reached mainstream popularity sometime after 1985 when MDMA was officially banned. It was used as a legal alternative to MDMA. 2C-B and the rest of the 2C- family were later banned in 1995.

2C-B: Specs & Technical Details

• 🐍 I understand why psychedelics should be treated with respect
• ⚖️ I’m familiar with the laws surrounding psychedelics in my country & state
• 🍄 I’m familiar and confident in the dose I’m taking (dose range for 2C-B is 5-20 mg)
• 🧪 I’ve tested a sample of the substance I’m using with  a drug testing kit
• 💊 I’m not mixing any medications or other substances with 2C-B
• 🏔 I’m in a safe & comfortable environment with people I trust
• 🐺 One of the members of my group is responsible and sober (AKA a  trip sitter )
• 📆 I have nothing important scheduled for after the trip
• 🧠 I’m in a sound & healthy state of mind
• 🌶 I’m aware of the increased risk of heatstroke & dehydration with this compound
• 📚 I’m familiar with the four pillars of responsible psychedelic use —  set, setting, sitter, & substance .
• ⏳ Know the timeline — the effects of 2C-B can last between 4 and 8 hours
• 🙅‍♀️ Know when to avoid stimulants — don’t take 2C-B if you have underlying heart, neurological, or psychiatric disorders

The dosage range for 2C-B is between 5 mg and 35 mg. Most tablets or capsules contain 5 mg of 2C-B each.

Lower doses of around 5 mg have effects most similar to MDMA or Adderall, while the higher doses (more than 15 mg) offer formidable hallucinogenic effects comparable to LSD, psilocybin, or mescaline.

The dosage range of 2C-B includes:

• 1 mg — Microdose
• 5 mg —  Threshold dose (stimulant-like effects)
• 5–20 mg — Standard psychoactive dose (hallucinogenic & stimulant effects)
• 20–35 mg —  High psychedelic dose (strong hallucinogenic & stimulant action)
• 35–60 mg —  Heroic dose (unpredictable effects, not recommended)

2C-B has a high level of safety. Shulgin, the inventor of the drug, reportedly took 100 mg by accident. This is a dose nearly three times what’s considered a high dose for the substance. He didn’t suffer any severe side effects from the experience.

With that said, higher doses can be intense. Most people who use more than 35 or 40 mg of the drug report intense, often scary, or confronting hallucinations.

The higher the dose, the stronger the visuals. Some could even describe the visuals at higher doses to be “cartoon-like” — which is similar to the visuals experienced with higher doses of mescaline.

The effects of 2C-B could be described as a combination of MDMA and LSD.

While there’s truth to this, it’s not perfectly accurate. 2C-B has empathogenic effects like MDMA and hallucinogenic effects like LSD — but the experience is unique in and of itself. The overall effects of 2C-B share much more resemblance to mescaline.

As part of our ongoing experience surveys, we ask our readers to share their experiences to better understand the effects and common dosages of substances.

Most of the responses we’ve received throughout our 2C-B survey had a positive sentiment. Many people taking part in our surveys and in the psychedelic community at large consider 2C-B to be their favorite psychedelic.

Commonly 2C-B Experiences Include:

• Increased energy (92%)
• A greater sense of empathy with others (86%)
• Introspection (80%)
• Visual hallucinations (78%)
• Sexual arousal (78%)
• Laughter (76%)
• Auditory hallucinations (67%)
• Ego death or dissolution (65%)

2C-B is most often used in place of MDMA at concerts, parties, or music festivals. The stimulating and euphoric effects make people feel more social and engaged, it creates a strong sense of empathy and connectedness with other people, and it won’t inhibit your ability to sleep at the end of the night.

Here’s what you can expect to feel while taking 2C-B:

Introspection

Users often report feelings of introspection, ego-dissolution , and a stronger sense of empathy and connection with others. It’s not uncommon for people using 2C-B to come to some sort of “realization” about their life. This realization may remain after the trip, but it may also be forgotten.

In a clinical setting, 2C-B is thought to connect the user with former emotions and repressed memories.

Hallucinations

2C-B is a hallucinogen through and through. In smaller doses these effects are limited, but higher doses of 2C-B produce intense changes in sensory perception . This includes sight, sound, and touch.

The visuals of 2C-B remind me of the videogame Borderlands — where some details pop much more than others and make the world look almost as though it was traced over with a pencil

Sometimes 2C-B can feel a little bit “speedy” or “tweaky” — especially in the higher doses.

2C-B is also used for its sexual-enhancement purposes as a way to explore a deeper connection between partners and enhance libido and physical stamina.

• Disorientation

Reports from people who took part in our survey that used very high doses (40 mg or higher) or mixed 2C-B with other psychedelics like LSD or psilocybin often mention the experience to be “disorientating” (37%).

2C-B isn’t used medically because of its current standing as a Schedule I substance in the United States. It’s classified under equivalent filings in other countries, such as the United Kingdom, Canada, Australia, Germany, and Europe.

The drug’s creator, Alexander Shulgin, suggested 2C-B was a good follow-up treatment in psychotherapy after MDMA. He suggested 2C-B as a way to open up the emotional, intuitive and archetypal area of your psyche to help solve the problems uncovered during the MDMA session.

More research is needed before we can make any reasonable assumptions about the potential for using 2C-B in psychotherapy.

Yes, 2C-B is a strong psychedelic — especially in higher doses. However, when used within the standard psychoactive range (5–15 mg), 2C-B is unlikely to lead to what can be considered a “bad trip.”

The higher you go over the 15 mg dose, the more likely you are to experience challenging or uncomfortable experiences. The hallucinations on 2C-B can escalate very quickly at higher doses.

Sometimes, bad trips are the result of adulterants (ingredients you weren’t expecting to be in there). Samples of 2C-B have been shown to contain substances such as methamphetamines, MDA, PMA, PMMA, NBOMe , or various opiates.

You should also always test a sample of your 2C-B using a reagent test liquid before you use it. It’s impossible to know what’s in a pill or powder without testing.

Testing 2C-B is very easy to do, it’s cheap, and it only requires you to sacrifice trace amounts of your tablet or powder — only a sample the size of a grain of sand is necessary to run the safety tests that could save your life.

One of the biggest benefits of using 2C-B over MDMA is the lack of a hangover the following morning.

Of our respondents, only 7% reported any negative impact the following morning after using doses lower than 35 mg of 2C-B. A big reason for this comes down to the fact that 2C-B rarely interferes with sleep. Getting a good night of rest after using 2C-B is one of the best ways to avoid hangovers.

With that said, hangovers are still possible — and are especially common with the higher doses. Of the survey respondents that too more than 35 mg of 2C-B, nearly 28% of them had a hangover the following morning.

The best way to avoid a 2C-B hangover is to drink plenty of water throughout the experience and ensure you’re getting a full 8 hours of sleep afterward. Taking some electrolytes or magnesium before you go to bed can go a long way as well.

2C-B usually lasts between 4 and 8 hours.

The effects usually begin to appear within about 45 minutes to an hour after taking it and peak around the 2-hour mark.

Peak effects last between 1 and 2 hours before tapering off. The comedown on 2C-B is very slow and gradual — which is considered one of the advantages of this substance. Most amphetamines or other stimulants tend to produce a rapid comedown — which can make users feel depressed. 2C-B is much more gradual and gentle.

2C-B comes as either a white crystalline powder or pressed tablets.

Tablets contain either 5, 10, 20, or 25 mg of 2C-B each — so a normal dose can range anywhere from 1–7 tablets. Always check the dose of your tablet before you take it.

The powder is usually used in a “parachute” — which involves weighing the dose of powder on a small scale and wrapping it up into a rolling paper. This is then taken just like you would a capsule, by essentially swallowing it whole.

Other people prefer to fill their own capsules using the raw powder or snorting it (insufflation). Be very careful when snorting any substance. The effects will be much stronger and appear much more quickly. Take a lower dose than you normally would and give it time to take effect. It’s easy to take too much using this method.

In general, we advise against snorting any substance. It’s far too easy to take too much, and it can be extremely damaging to the nasal cavity.

Additionally, always weigh your dose using a small scale if you’re taking the raw powder. Never attempt to eyeball your dose of 2C-B of any powdered drugs. Scales are cheap (less than $20) and could mean the difference between having a positive experience and ending up in a hospital.

2C-B can also be vaporized — but this isn’t a common way of using it, and the long-term health effects of taking 2C-B this way aren’t well understood. Many compounds will change when heated like this, and the byproducts of vaporized 2C-B are not well understood.

It’s best to stick to the tried and tested oral route when taking 2C-B.

2C-B is just one of many substances in its family. Most of them were invented around the same time by Alexander Shulgin and documented in one of his books PiHKAL .

All 2C- substances contain methoxy groups on the 2 and 5 positions of a benzene ring of its chemical structure. They each have a unique chemical group attached to the 4th position on the benzene ring, which is what differentiates them in terms of their chemical structure and effect profile.

When various government regulators started banning 2C-B, they did so by banning the entire 2C-x family — as defined by the chemical structure above.

The most notable members of the 2C- family include:

• 2C-B — this is by far the most popular member of the family.
• 2C-C — this 2c compound differentiates itself through its relaxing, even mild sedative action and powerful visuals.
• 2C-E —  this 2C compound is milder than 2C-B, has a slightly higher likelihood of side effects, and lasts about 3 hours longer.
• 2C-I — these substances tend to produce effects similar to LSD but less introspective. The most common is 2C-I-NBOMe, which has been proven to be dangerous & should be avoided
• 2C-P —  a strong, but mellow psychedelic with empathogen underpinnings.
• 2C-T — there are several iterations of this compound, including 2C-T-2, 2C-T-3, 2C-T-4, 2C-T-7, & 2C-T-16. The most popular, by far, is 2CT-7.

List of all 2C-Substances

How strong is 2c-b vs. other psychedelics.

The intensity of effects from 2CB increases steadily along with the dose.

Lower doses (5 mg) resemble Adderall or MDMA and don’t produce strong visuals.

The higher the dose, the more psychedelic it gets. The 35 mg dose is a potent psychedelic — and very high doses (50 mg or more) are profoundly psychedelic and have even been known to induce out-of-body experiences.

2C-B is often compared to LSD because the visual effects of these two drugs are very similar. Users experience light trails, geometric patterns, and objects that appear to merge together.

The intensity of the trip is very similar for these two drugs, but 2C-B is generally much more euphoric. Some people argue the euphoria induced by 2C-B isn’t “earned.” This means you don’t actually have to do anything to feel the euphoria; it’s merely a byproduct of the substance itself.

With LSD, the euphoria needs to be earned through experience and mindset. It doesn’t have an inherent euphoric quality to it, so those without the right mindset may not feel any euphoria whatsoever.

In terms of dose, LSD is many times more potent than 2C-B. The psychoactive dose of LSD is measured in sub-milligram doses, while the threshold dose for 2C-B is around 5 mg.

Most people suggest the effects of 2C-B are a combination of LSD and MDMA. However, it’s more accurate to suggest the effects of 2C-B resemble mescaline — which is actually the molecule used as inspiration for creating the entire 2C class of drugs, to begin with.

2C-B is more stimulating than mescaline and has much less “headspace.” Headspace refers to the introspective and existential thoughts that accompany the psychedelic experience.

Both 2C-B and mescaline are thought of as being “gentle” when compared to other psychedelics and the visuals are very similar between the two.

In lower doses, their visuals are very “flowy”, while higher doses are much more “cartoon-like.”

2C-B is often used as an alternative to MDMA (ecstasy) at concerts, music festivals, or parties. Lower doses of 2C-B are the most similar to MDMA for creating a greater sense of connectedness with the people around you. Both substances produce a feeling of euphoria, can enhance the enjoyment of music, and stimulate the sensual feedback from touch.

The more 2C-B you take, the further the experience diverges from MDMA. High doses are very psychedelic and can make being at public events very uncomfortable — unlike MDMA.

One of the main benefits of 2C-B over MDMA is that users usually don’t experience difficulty falling asleep after the experience.

Is 2C-B Safe?

There are no reported overdose deaths from people who took 2C-B. Additionally, the few clinical trials that are available involving 2C-B have all reported the drug had little to no side effects and that the drug had a high level of safety.

Anecdotal reports on sites like Reddit, as well as through our own surveys, suggest some people prefer to take large doses of the drug (over 50 mg) — without experiencing any severe side effects.

The lethal dose of 2C-B has never been found.

Some users, including Shulgin, have reported taking as much as 100 mg of 2C-B without serious side effects. However, these doses are rarely enjoyable and can even be quite scary.

2C-B has been around since the 1970s, and while it didn’t really become popular until the 90s, it still has over 30 years of mainstream use behind it. If 2C-B was inherently dangerous, it would be crystal clear by now.

With that said, there is a serious lack of research available on the safety of 2C-B. There are virtually no toxicology studies available. Due to the heavily restricted status of this substance, it’s unlikely we’re going to see this research anytime in the near future.

This isn’t the case with other 2C substances — such as 2C-E and 2C-I — which have proven themselves dangerous over the years.

With that said, 2C-B isn’t without its risks.

The main risk of this compound is adulteration (mixing or swapping other substances into 2C-B tablets or powder).

It’s not uncommon for someone to order 2C-B online only to receive something completely different in the mail. You can never trust what’s inside your pills or powders unless you test it first. And even with testing, you can’t be 100% sure it’s free from harmful chemicals.

→ Learn how to test a sample of 2C-B for adulterants

Certain drugs or medications may also interact negatively with 2C-B.

This substance is largely metabolized by an enzyme called monoamine oxidase (MAO) [ 2 ]. It’s the main enzyme responsible for breaking down neurotransmitters, including dopamine, serotonin, and norepinephrine. People taking MAO inhibitor medications (a type of antidepressant) may have a hard time metabolizing 2C-B — which could lead to side effects.

2C-B is also likely to interact negatively with other stimulating substances, such as amphetamines (Adderall), MDMA, MDA, cocaine, caffeine, and nicotine. Combining these substances could lead to side effects and harm involved with increased heart rate and blood pressure, changes in breathing patterns, jitteriness and muscle tension, dehydration, headaches, blood sugar regulation, and anxiety or panic.

Mixing 2CB with other psychedelics like LSD, mescaline, or magic mushrooms can lead to much stronger hallucinations. This can cause intense fear, panic, or anxiety.

It’s wise to avoid any other substances while taking 2C-B to avoid negative interactions. This includes alcohol, cigarettes, and prescription medications.

People taking heart medications, immune system regulators, antibiotics, or ADHD medications should avoid 2C-B altogether.

• Fear, panic, or anxiety
• Nausea & vomiting
• Digestive discomfort
• Rapid heart rate
• High blood pressure

2C-B is not inherently addictive — however, people can form addictions to any mind-altering substance, including 2C-B.

There really isn’t such a thing as a “good drug” or a “bad drug.” Substances like 2C-B are just molecules that exist in the world around us. It’s our relationship to them and the way we use them that can be described as “healthy” or “unhealthy.”

An unhealthy relationship with a substance like 2C-B would involve regular, repeated use of the substance either out of compulsion or to find a release from reality.

This is essentially what addiction is. They’re using a substance to escape the way they feel or to escape a reality they deem “undesirable.”

2C-B makes us happy, carefree, relaxed, social, and euphoric. It changes our perspective of the world and allows us to forget our biggest fears and stressors.

While this can be extremely beneficial for helping someone acknowledge the source of their problems internally and acts as a reminder that life, in its essence, is good — it can also become a crutch for people with more of a nihilistic or doomer perspective on life.

Compulsive use of any substance would be an example of having an unhealthy relationship with the substance. It’s what defines addiction.

Psychedelics like 2C-B should be used for personal growth and healing — not to escape reality.

2C-B & Physical Addiction: Dependence & Tolerance

There are two types of addiction — behavioral addiction and physical addiction.

As described above, behavioral addiction is the type of addiction we can have for the way a substance or activity makes us feel. Our body isn’t dependent on the substance, but we still seek it out in order to feel a certain way. We can also become behaviorally addicted to gambling, sex, masturbation, or shopping.

Physical addiction is differentiated from behavioral addiction in that there is a physical change to the body’s homeostatic default settings in response to the drug. When we take a substance repeatedly, the body makes changes to adapt to the presence of the substance. This is called dependence because we depend on having the drug in our system to maintain balance. As soon as the drug wears off, we’re no longer in balance — causing side effects referred to as withdrawal.

2C-B can eventually lead to physical addiction if used repetitively over long periods of time.

All 2C substances are illegal globally. The entire family of research chemicals was originally banned in the United States in 1995. 2C-B was specifically added to the UN Convention of Psychotropic Substances in 2001 . This led to the banning of this substance in all UN-member countries.

In the US, 2C-B is listed as a Schedule I drug — along with heroin, LSD, and cocaine.

It’s classified as a Schedule III substance in Canada, which means it’s only available for research purposes.

In the United Kingdom, 2C-B is a Class A drug — which implies the drug poses a significant danger to public health and brings the most severe punishments to those caught in possession of the drug.

Related: What is psychedelic-assisted psychotherapy?

There isn’t much research available on 2C-B, but we do have a general understanding of how it works.

Most psychedelics work by activating the 5-HT2A serotonin receptors. This is the primary mechanism of action employed by substances, including LSD, DMT, and psilocybin.

2C-B and related phenethylamines like mescaline have a much weaker action on this receptor. This suggests there are other mechanisms involved with the drug’s hallucinogenic effects. Some studies even suggest 2C-B may act as an inhibitor of the 5-HT2A receptor [ 3 ].

Some studies suggest 2C-B activates another serotonin receptor called 5-HT2C — which also produces hallucinogenic effects [ 4 ].

Other serotonin receptors may also be involved, such as the 5-HT1A receptors, which could be involved in the emotional changes induced by 2C-B [ 5 ]. This substance is reported to influence the emotional response through both top-down and bottom-up cognitive processes.

Compared to other 2C-x drugs, 2C-B is the second most potent agonist of serotonin receptors only to 2C-I. 2C-D and 2C-H have a much lower affinity for these receptors.

2C-B has also been shown to have some action at the alpha-adrenergic receptors [3]. This is likely one of the main mechanisms involved with the substance’s stimulating effects.

Research on 2C-B is seriously lacking. Despite how popular this substance is, there are no clinical trials or even toxicology studies to date. The only data we have available comes from anecdotal reports, observational studies, and in vitro research. If you want to contribute your experience to improve our understanding of 2C-B or other psychedelics, consider filling out one or more of our psychedelic surveys and sharing your experience.

Frequently Asked Questions About 2C-B

Everybody should test their drugs before using them to avoid mistakenly consuming toxic alternatives.

The best way to test a sample of 2C-B is to use a reagent test kit. Only a small sample of the drug is needed to run the test (the size of a grain of sand).

Regent tests won’t tell you the purity of a substance. They can only tell you whether or not a sample contains a certain substance or not.

The best reagent to use is the Marquis reagent. It will turn a yellowish-green color in the presence of 2C-B. The reagent will turn purple if the sample contains MDMA, and NBOMe substances will turn red.

Most drug tests won’t detect 2C-B. Only specialized drug tests using mass spectrometry or gas chromatography will be able to differentiate 2C-B in a blood or urine sample.

There have been reports of 2C-B triggering a false-positive on amphetamine tests, but this is very rare.

With that said, if you’re expecting a drug test for any reason, it would be wise to avoid 2C-B.

All psychoactive drugs have an inherent level of risk associated with their use. 2C-B has stimulating effects that could be dangerous for people with heart disease or who are taking heart medications.

The hallucinogenic effects of 2C-B could bring an increased level of risk to people with psychiatric disorders.

2C-B has never been associated with any overdoses or deaths, but there’s been one case of reported psychosis after using 2C-B [ 7 ].

Microdosing is the process of taking very small, sub-perceptual doses of a substance. They’re used to increase focus and concentration, improve empathy and connectedness with others, and help achieve a higher level of productivity.

Some users have reported taking microdoses of 2C-B similarly to other psychedelics like magic mushrooms or LSD. It’s been reported to increase tactile awareness, increase the clarity of thought, and boost mental energy and stamina.

It’s not clear whether or not microdoses of 2C-B are safe long term.

Final Thoughts: What Is 2C-B?

2C-B is one of the most popular psychoactive substances globally — despite there being virtually no research available on its safety or effect profiles in the medical literature.

It’s often used as an alternative to MDMA at lower doses and an alternative to LSD in high doses.

Compared to other psychedelics, 2C-B is considered gentle — which effects described as being a combination of MDMA and LSD. A better comparison is mescaline — which is the molecule Alexander Shulgin used to derive the 2C class of drugs, to begin with.

We’re running a continual survey on the use of 2C-B to better understand the effects and use patterns surrounding this unique psychedelic substance.

If you’ve tried 2C-B and want to contribute to this research, you can anonymously enter details of your experience through this  6-minute 2C-B survey . We greatly appreciate your participation!

• Carmo, H., Hengstler, J. G., De Boer, D., Ringel, M., Remião, F., Carvalho, F., … & de Lourdes Bastos, M. (2005). Metabolic pathways of 4-bromo-2, 5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species, including human. Toxicology, 206(1), 75-89.
• González, D., Torrens, M., & Farré, M. (2015). Acute effects of the novel psychoactive drug 2C-B on emotions. BioMed research international, 2015.
• Villalobos, C. A., Bull, P., Sáez, P., Cassels, B. K., & Huidobro‐Toro, J. P. (2004). 4‐Bromo‐2, 5‐dimethoxyphenethylamine (2C‐B) and structurally related phenylethylamines are potent 5‐HT2A receptor antagonists in Xenopus laevis oocytes. British journal of pharmacology, 141(7), 1167-1174.
• Rickli, A., Luethi, D., Reinisch, J., Buchy, D., Hoener, M. C., & Liechti, M. E. (2015). Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2, 5-dimethoxy-substituted phenethylamines (2C drugs). Neuropharmacology, 99, 546-553.
• Papaseit, E., Farré, M., Pérez-Mañá, C., Torrens, M., Ventura, M., Pujadas, M., … & González, D. (2018). Acute pharmacological effects of 2C-B in humans: an observational study. Frontiers in pharmacology, 9, 206.
• Huang, H. H., & Bai, Y. M. (2011). Persistent psychosis after ingestion of a single tablet of’2C-B’. Progress in neuro-psychopharmacology & biological psychiatry, 35(1), 293-294.

What Is Nexus Flipping?

2C-I: An Obscure, But Powerful Research Chemical

Alexander Shulgin: The Godfather of Psychedelics

2C-T-7: A Mixed Bag of Psychedelic Tricks

2C-P: The Strongest Member of the 2C Family of Psychedelics

2C-D: The Intersect Between DOM & 2C-B

2C Psychedelics

2C-T-2: Potential Therapeutic Alternative to MDMA?

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• Psychedelics

Last published: March 14, 2024

What is 2C-B?

2C-B (4-Bromo-2,5-dimethoxyphenethylamine) is a psychedelic drug, which means it can affect all the senses, altering a person’s thinking, sense of time and emotions. Psychedelics can cause a person to hallucinate, seeing or hearing things that do not exist or are distorted. 1

2C-B is part of the ‘2C’ group of drugs, which is a general name for phenethylamines. 2

The '2C' group of drugs are psychedelic but can also cause stimulant effects. Drugs from this group include 2C-C, 2C-P, 2C-E and 2C-I. The effects vary among each drug in this group. 2

What does 2C-B look like?

According to anecdotal user reports, 2C-B usually comes as a white powder or crystal and is sometimes pressed into a tablet similar to MDMA. 3

Other names

Nexus, BDMPEA, Venus, Bees 3

Other types of psychedelics

• Psilocybin (magic mushrooms)

How is 2C-B used?

2C-B is usually taken via the mouth (orally). 2C-B can be snorted, but anecdotal reports suggest this method of use can be very painful. 4

Effects of 2C-B

There is no safe level of drug use.  Use of any drug always carries some risk. It’s important to be careful when taking any type of drug. 

Psychedelics affect everyone differently, based on:

• size, weight and health
• whether the person is used to taking it
• whether other drugs are taken around the same time
• the amount taken
• the strength of the drug (varies from batch to batch)
• environment (where the drug is taken).

2C-B affects everyone differently, but effects may include:

• increased blood pressure and heart rate
• nausea and vomiting
• feelings of well-being
• anxiety and panic
• change in perception
• hearing sounds
• sexual arousal
• hallucinations
• insomnia. 2, 4

The effects of 2C-B typically last from four to eight hours. There have been anecdotal reports it can last for up to 12 hours. 3

Impact of mood and environment

Drugs that affect a person’s mental state (psychoactive drugs) can also have varied effects depending on a person’s mood (often called the ‘set’) or the environment they’re in (the ‘setting’).

Set is a person’s state of mind, previous encounters with psychedelic drugs, and expectations of what’s going to happen. For example, feelings of stress or anxiety before using 2C-B may result in an unpleasant experience (bad trip). 5

Setting is the environment in which someone consumes 2C-B – whether it’s known and familiar, who they’re with, if they’re indoors or outdoors, the type of music and light. For example, using 2C-B in a calm, quiet and relaxed environment could lead or contribute to a pleasant experience but being in a noisy, crowded place may result in a negative experience. 5

Being in a good state of mind, with trusted friends and a safe environment before taking 2C-B reduces the risk of having a ‘bad’ trip.

There have been no reported deaths from 2C-B, but deaths have occurred from the use of other 2C drugs. 2

Coming down  

According to anecdotal user reports, the after-effects or comedown of taking 2C-B can last for around 2-4 hours. 3

Long-term effects

To our best knowledge, there have been no scientific studies into the long-term effects of 2C-B use.

2C-B and mental health  

People with a family history of mental illness are more likely to experience anxiety or paranoia after using 2C-B. This is consistent with what the evidence tells us about people with mental illness and psychedelic use. 6

Bad trips  

Some people may have negative experiences taking psychedelics, or experiences they find challenging. This can include experiencing:

• frightening or confronting hallucinations
• intense anxiety and confusion
• fear and paranoia. 5, 7

Tolerance and dependence

Similar to other psychedelics, 2C-B does not produce dependence. Some people that use 2C-B report a tolerance to it after regular use (more than once every five to seven days). 3

Mixing 2C-B with other drugs  

The effects of taking 2C-B with other drugs − including over-the-counter or prescribed medications − can be unpredictable and dangerous.

2C-B + cannabis = a more intense psychedelic experience which could result in anxiety and increase the chances of having a ‘bad trip’. 8

2C-B + tramadol = a lowering of the seizure threshold. May cause seizures in predisposed individuals. 9, 10

More on polydrug use

‘Polydrug use’ is a term for the use of more than one drug or type of drug at the same time or one after another.1 Polydrug use can involve both illicit drugs and legal substances, such as alcohol and medications.

Reducing harm

• Start with a lower dose until you know how the drug affects you personally. It will be different for everyone due to factors such as weight, tolerance and metabolism.
• Always weigh the 2C-B before use, using a milligram scale. A 15mg dose will produce a very different experience to a 30mg dose.
• Consider the impact of mood and environment.
• Consider having a person to 'trip sit'. A person who remains sober and that can help out if needed.
• Avoid snorting as anecdotal user reports are this is extremely painful and can damage your nose and cause nose bleeds. 3, 11

There is limited information regarding regular use of 2C-B and withdrawal symptoms.

Getting help

If your use of 2C-B is affecting your health, family, relationships, work, school, financial or other life situations, or you’re concerned about a loved one, you can find help and support.

Call the National Alcohol and Other Drug Hotline on 1800 250 015 for free and confidential advice, information and counselling about alcohol and other drugs

Help and Support Services search

Find a service in your local area from our list. Simply add your location or postcode and filter by service type to quickly discover help near you.

If you're looking for other information or support options, send us an email at [email protected]

Not sure what you are looking for? Try our intuitive Path2Help tool and be matched with support information and services tailored to you.

2C-B is a schedule 9 drug and use of 2C-B is against the law. Federal and state laws provide penalties for possessing, using, making, selling, importing or exporting, or driving under the influence of 2C-B. 12

In 2021, 6% of respondents to the National Ecstasy and Related Drugs Reporting System reported using a 2C type of drug. 13

• Nichols D. Psychedelics. Pharmacological Reviews 2016;68:264–355.
• Vang Dean B, Stellpflug S, Burnett A, Engebretsen K. 2C or Not 2C: Phenethylamine Designer Drug Review. Journal of Medical Toxicology 2013;9(2):172-8.
• Psychonaut Wiki. 2C-B 2022 [cited: 27.06.2022].
• Papaseit E, Farré M, Pérez-Mañá C, Torrens M, Ventura M, Pujadas M, et al. Acute Pharmacological Effects of 2C-B in Humans: An Observational Study. Frontiers in Pharmacology. 2018;9.
• Nutt D. Drugs without the hot air: making sense of legal and illegal drugs. Cambridge: UIT Cambridge Ltd; 2012.
• Krebs T, Johansen P. Psychedelics and Mental Health: A Population Study. PLoS One. 2013;8(8).
• Brands B, Marshman J, Sproule B. Drugs & Drug Abuse: A Reference Text: Addiction Research Foundation. Fondation de la recherche sur la toxicomanie; 1998.
• Strassman R. Adverse Reactions to Psychedelic Drugs A Review of the Literature. The Journal of Nervous and Mental Disease 1984;172(10).
• Talaie H, Panahandeh R, Fayaznouri MR, Asadi Z, Abdollahi M. Dose-independent occurrence of seizure with tramadol. The Journal of Medical Toxicity 2010;5(2).
• National Drug and Alcohol Research Centre. Tramadol 2021 08.06.2022. Available from: https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/NDARC%20Fact%20Sheet_Tramadol.pdf .
• Harm Reduction Victoria. 2C-B and the 2C family n.d. [27.06.2022]. Available from: https://www.hrvic.org.au/resources .
• Australian Government. Federal Register of Legislation The Poisons Standard 2021.
• Sutherland R, Karlsson A, Price O, Uporova J, Chandrasena U, Swanton RG, et al. Australian Drug Trends 2021: Key Findings from the National Ecstasy and Related Drugs Reporting System (EDRS) Interviews. UNSW 2021.

Explore psychedelics on the Drug Wheel

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Last updated: 14 Mar 2024

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Bestival death may be world's first 2C-P fatality, court hears

Experts find no evidence drug taken by Louella Fletcher-Michie has killed anyone

A young woman who died at a music festival is believed to be the first person in the world to die after taking the substance 2C-P, a court has been told.

Jurors heard that the drug, which Louella Fletcher-Michie, 24, took at the Bestival event in Dorset, could cause hallucinations and agitation, but experts could find no evidence it had led to a user’s death.

Fletcher-Michie’s boyfriend, Ceon Broughton, 29, is on trial accused of her manslaughter and supplying her with 2C-P. The musician, from Enfield, north London, denies the offences.

The prosecution said Broughton did not immediately seek help for Fletcher-Michie, the daughter of the Holby City actor, John Michie, because he was serving a suspended jail sentence and feared imprisonment.

Jurors have been told Fletcher-Michie screeched like an animal after having a “bad trip”, and scraped thorns across her face and ate twigs.

The forensic pathologist Dr Russell Delaney told Winchester crown court on Wednesday that the synthetic substance could cause “potent hallucinations and agitation”, an abnormally fast heart rate and increased blood pressure, as well as raising body temperature.

He said there had been reports of people in the US being admitted to hospital having taken 2C-P, but they had been saved after being treated with a defibrillator. Delaney said smaller amounts of MDMA and ketamine were also found in Fletcher-Michie’s bloodstream.

The pathologist told the court Fletcher-Michie had cuts and bruises on her arms and legs, as well as bruising to her nose and cuts on her face.

He said: “[Her] agitated behaviour continued over a number of hours ... Her boyfriend describes restraining her and it requiring all his might.”

During his cross-examination of Delaney, Stephen Kamlish QC, representing Broughton, said: “There are no deaths in world literature attributed to 2C-P, a fact which has been fully researched by both the prosecution and defence in this case.”

The toxicologist Dr Stephen Morley told jurors: “As far as I can tell, there has never been a recorded case in scientific literature of 2C-P causing a death.”

Morley added: “We have to be very careful when talking about dosages, but Alexander Shulgin, who created the 2C group drugs and tested them on himself and a small group of colleagues, showed most doses are between six and 10 milligrams.

“He once took a single dose of 16 milligrams and said it was a physical disaster not to be repeated. You can have a very small increase in the amount you take and it can have a very detrimental effect.

“Shulgin’s original work said if you took 10 to 12 milligrams it can have a pleasurable effect, but even a small increase to him had a far more negative effect. A bump up may have a far greater negative effect than a straightforward dosage.”

The trial continues.

More on this story

Court overturns man's conviction for girlfriend's Bestival drug death

Musician jailed over girlfriend's drug death at bestival.

Bestival death: man convicted 'has history of giving women drugs'

Bestival death: man guilty of killing actor's daughter he supplied with drugs.

Bestival drug death trial: accused will not give evidence

Bestival death: actor's daughter 'tried to eat twigs' after taking drug

Bestival death: actor tells court daughter's boyfriend left her to die.

Party drugs killed TV actor’s daughter at music festival, court hears

Most viewed.

2C drugs – such as 2CB, 2CI and 2CE – have hallucinogenic and stimulant effects

Also called:

• Seventh-Heaven

How the drug works varies from person to person

How it looks, tastes and smells

What does it look like.

• A small pill
• A powder, usually white but not always
• A liquid, but this is rare

2C drugs are normally sold as pills or powders, but this can vary. For example, 2CB and 2CT-7 have been sold as white powders or small 5mg pills.

A liquid form of 2CI has been reported, but this is rare.

What does it taste/smell like?

Users say that 2Cs can give a burning sensation and be painful to snort.

How do people take it?

The 2C drugs can be snorted, swallowed or smoked.

How it feels

How does it make you feel.

The 2C family of drugs are classed as psychedelics (hallucinogens) but they can also produce stimulant effects.

As hallucinogens, they can make you experience reality in a distorted way that may cause hallucinations (seeing and hearing things that aren’t there).

As stimulants, they can make you feel awake, alert and affectionate towards people around you.

The 2C drugs can make you:

• energised and alert
• extra aware of colours, sounds and smells
• very sensitive to touch and sexually aroused

They can also make you:

• happy and in tune with your surroundings (similar to ecstasy ), especially if taken in smaller doses
• see the world around you as being distorted, this is sometimes called ‘visuals’
• hallucinate, especially if taken in larger doses

As with all psychedelic drugs, it’s very hard to predict how you’ll feel when you take a 2C drug – and some 2Cs cause more psychedelic effects than others. The more you take, the more intense and uncontrollable the experience will be.

How does it make people behave?

Because 2C drugs produce effects that are similar to both ecstasy and psychedelic drugs like LSD , people can behave like they’re on ecstasy or LSD – or both.

How long the effects last and the drug stays in your system depends on how much you’ve taken, your size and what other drugs you may have also taken.

Physical health risks

Taking 2C drugs involves risks. Here’s what we know:

They can cause headaches, nausea and vomiting.

There is a risk of over-stimulating the heart and circulation.

It’s not yet known if 2C drugs cause any long term damage, but there have been numerous hospitalisations associated with their use.

Mental health risks

Because the 2Cs are psychedelic drugs, anyone with a history of mental illness should be particularly careful.

Here’s what we know:

Panic attacks have been reported.

Severe psychosis has been reported.

Confused, agitated or even delirious states have been reported when the drugs have been taken in high doses.

Evidence from other drugs – such as ecstasy and LSD – suggest that regular users of the drugs become tired, low in mood and anxious when they stop using, or if they use in high doses.

What is 2C family cut with?

Information about 2C purity is difficult to get hold of.

Is it dangerous to mix with other drugs?

Mixing drugs is always risky but some mixtures are more dangerous than others.

What happens if I mix 2C family and

Can you get addicted.

There’s very little current information about 2C drugs’ addictiveness.

Tolerance and psychological dependence have been reported in stimulant drugs, such as ecstasy , that act like 2C drugs but little is known about the effects of 2C drugs themselves.

This is a Class A drug, which means it's illegal to have for yourself, give away or sell.

Possession can get you up to 7 years in prison, an unlimited fine or both.

Supplying someone else, even your friends, can get you life in prison, an unlimited fine or both.

Like drink-driving, driving when high is dangerous and illegal. If you’re caught driving under the influence, you may receive a heavy fine, driving ban, or prison sentence.

If the police catch people supplying illegal drugs in a home, club, bar or hostel, they can potentially prosecute the landlord, club owner or any other person concerned in the management of the premises.

Was this information useful?

The Ultimate Guide to 2C-B

(nexus, venus, bromo mescaline, bees, toonies).

2C-B is a potentially illegal substance, and we do not encourage or condone the use of this substance where it is against the law. However, we accept that illegal drug use occurs, and believe that offering responsible harm reduction information is imperative to keeping people safe. For that reason, this guide is designed to ensure the safety of those who decide to use the substance.

2C-B has been used as an aphrodisiac, entheogen, dance drug, ecstasy adulterant, and psychotherapeutic aid. However, it has yet to gain widespread acceptance and it has been banned in most countries since the mid-1990s.

What to expect

Shulgin claimed that 2C-B was one of his favorite psychedelics, and wrote in 2003 that the drug was “one of the most graceful, erotic, sensual, introspective compounds I have ever invented.” [1] Many people report that the experience has the groundedness of mescaline, the empathy of MDMA, and the visuals of mushrooms or LSD, but with more connection to reality. It’s known for enhancing one’s senses and feelings and amplifying visuals, sound, and touch.

2C-B is usually swallowed in the form of a tablet, capsule, or powder, which can also be dissolved in liquid. The threshold oral dose is 2-5 mg, while a light effective dose is around 5-15 mg. Most people take between 15 and 25 mg for a full experience, and anything above that is considered strong. 50 mg seems to be a good upper limit. [2]

The onset of 2C-B lasts about 45-75 minutes, with a 15-30 minute “coming up” period. During this time, it’s common to feel a sense of anticipation or even anxiety. This is often coupled with a pleasurable warmth or tingling—like electricity or pins and needles—going up and down the body. There may be signs of physical and sexual arousal, including raised hairs, muscle spasms, erection, chills, tremors, and dilated pupils. Some people report experiencing gastrointestinal issues such as gas, nausea, vomiting, and diarrhea.

At high enough doses, 2C-B produces visual effects, which often include geometric patterns, after-images and tracers, facial distortions, environmental drifting (e.g. melting or flowing surfaces), and enhanced or shifting colors. Closed-eye visuals are often richer, with profound fantasy imagery. Auditory hallucinations are also common. At higher doses, these hallucinations can become unpleasant, ugly, or even frightening.

Peak effects

The peak effects of the 2C-B experience last for two to four hours. Any nausea and discomfort have generally faded by this point. Touch, smell, taste, color, and sound all tend to be enhanced during this time, and many people report feeling squarely “in the body”—aware of their muscles and nerves and merging with physical nature. Unlike on MDMA, sexual arousal can be maintained throughout the 2C-B experience.

During the peak, people report enhanced moods and feelings of stimulation, but with less “pushiness” than MDMA. People often describe 2C-B as far more malleable, allowing them to go in and out of baseline consciousness, sometimes abruptly, even during peak effects. Others find themselves dealing with difficult emotions such as anger, grief, and fear.

Communication can break down during the height of a 2C-B experience, although talking to others can become easier for some people. In any case, people usually see an increase in their empathy and sociability. Conceptual thinking, introspective insights, and spiritual ideation are also common—especially when alone. There may be a slight softening of the ego.

Coming down and after the trip

Pharmacology.

Phenethylamines like 2C-B are known as “simple” psychedelics for their one-ring structure—contrasted with the more complex structure of indoles (e.g. tryptamines). [12] [13] Some other phenethylamines include amphetamines, mescaline, mephedrone, ephedrine, and cathine and cathinone from khat. 2C-B gets its name from the two carbon atoms (2C) that join the phenyl ring to the amino group, and for the bromine atom (B) substituted at the R4 position. [14] Like the other 2Cs, 2C-B has methoxy groups at positions R2 and R5. [6]

Receptor binding

Not much is known about the pharmacodynamics of 2C-B, but it shows a binding affinity for the 5-HT2 serotonergic receptors. [14] Unlike the classical psychedelics, it selectively antagonizes (blocks) the 5-HT2A receptor subtype usually involved in hallucinogenic effects. [15] Its psychoactivity is thought to be at least partially related to the activation of 5-HT2C receptors or to signaling pathways coupled to 5-HT2A. [16] [17] Further activation of α1-adrenergic receptors may be responsible for 2C-B’s stimulant effects. [18]

Benefits & Risks

Though there isn’t much research into the psychological or physiological effects of 2C-B, there is plenty of anecdotal evidence that suggests it could be beneficial for both therapeutic purposes and personal/spiritual development. Shulgin himself recommended the use of this compound in therapy and gave it to a handful of psychologists to use with patients. He also suggested that the drug could be used in conjunction with MDMA to ease the comedown and solidify any revelations brought on by the experience.

People have also reported profound spiritual and personal experiences during a 2C-B trip, including feelings of connections to the self, others, and the universe, which can last long after the trip has come to an end.

2C-B is metabolized by the monoamine oxidases (MAOs) A and B, so it likely poses a risk for people on MAO inhibitors (MAOIs). [19] [20] These include some types of antidepressants, as well as ayahuasca.

Research into the safety of 2C-B is otherwise lacking, which could have a lot to do with its legal status. [19] [21] What we do know about the drug is mostly anecdotal. For instance, some users report taking up to 10 times the highest recommended dose with no lingering health problems. [3] [7] [22] [23] While some fatalities have been linked to other substances in the 2C family (including 2C-T-7 and 2C-I-NBOMe), none have been attributed to 2C-B alone. [14] That said, virtually nothing is known about the medium- to long-term health risks and some users may be more susceptible than others. [14] [19]

One female user experienced severe headaches, brain dysfunction, and weak limbs within 48 hours of taking liquid 2C-B. [24] In a similar sort of time frame, a male user with no family history of psychosis began to experience auditory hallucinations, increased irritability, and paranoid delusions. [25] These symptoms persisted for two months until he was treated with the antipsychotic medication risperidone. It should be noted, however, that in neither of these highly unusual cases was the presence of 2C-B confirmed. [19]

As with other psychedelics, set and setting are pivotal to the safety of a 2C-B experience. It’s best to avoid this drug during times of psychological distress, or too soon after difficult life experiences. [4] Public settings should also be avoided, at least to begin with. [7]

Because 2C-B can inhibit one’s spatial coordination and attention span, a space as free from hazards as possible is the ideal setting for an experience. The drug’s mild anesthetic effect can sometimes allow injuries to go unnoticed. [11] [26] Driving is especially dangerous while under the influence and should always be avoided.

Therapeutic Use

Shulgin—who is known as the “Godfather of Ecstacy”— believed the compound’s relatively short duration and empathogenic effects would be of value to psychologists and psychotherapists. [5] He was especially enthusiastic about its synergy with MDMA and believed the insights from an MDMA experience could be reinforced by using 2C-B at the end of an MDMA session, or even in a separate session. [29] [7]

After developing the drug, Shulgin gave it to a small handful of psychologists who found that the compound created a “warm, empathetic bond between themselves and their patients.” [30] They also reported that 2C-B helped their patients “get in touch with suppressed emotions and repressed memories, thereby helping to resolve psychological problems.”

Anecdotally, one user reported that the post-peak period of the 2C-B experience was conducive to working through general personal development stuff, as well as “accessing ‘earlier stages of my self’ and being able to use it in a way that’s meaningful for my present-day self.” In an amateur survey of 48 people who agreed to take 2C-T-7 (another Shulgin chemical similar to 2C-B), six participants said they experienced therapeutic or healing effects, including the resolution of deep emotional issues.

Personal Growth

Many users find 2C-B to be a kind of cathartic self-therapy tool, fostering powerful and sometimes life-changing insights about themselves and the nature of their reality. [33] [34] [35] Feeling “at one with the universe” is common, as are fresh perspectives on negative personality traits, thought patterns, and destructive behaviors. [11]

The malleability of the 2C-B experience allows users to focus on positive thoughts over negative ones and leads to an understanding of the impact of habitual thought processes. [36] According to psychedelic researcher D. M. Turner, 2C-B can also be used to strengthen parts of the ego while dissolving others, ultimately resulting in a more positive self-image. [10]

In South Africa, 2C-B (as Ubulawu Nomathotholo) has been linked to revelatory visions of spirit animals and tribal ancestors, including meetings with the Xhosa creator deity. Following these “journeys,” users reported becoming more confident and resolving longstanding grief, among other personal benefits. [30]

Like MDMA, 2C-B promotes empathy and understanding between people. One mother who took the drug with her son—who had recently moved away—learned how to let go as a parent and accept his individuality. Importantly for their relationship, she came to appreciate him as a separate, self-contained being. [37] Others report its usefulness in strengthening bonds between couples.

At present, 2C-B doesn’t appear to be legal in any country. It is illegal in the United States, Canada, the European Union (except the Czech Republic and Portugal), Australia, and more.

History & Stats

2C-B remained largely underground throughout its early days. It was first encountered by the DEA in 1979, but—aside from the seizure of several clandestine laboratories—no legislative action was taken. [40]

When MDMA was banned in 1985, 2C-B’s popularity surged as a legal alternative. [41] [27] It was also developed as an aphrodisiac by the German pharmaceutical company Drittewelle (meaning “third wave,” interestingly enough!), and marketed under the brand names Erox , Nexus, and Performax. [30] [42] By the early 1990s, America had become the world’s largest consumer of this over-the-counter treatment for impotence and “frigidity,” although many were using it for its psychedelic effects. [30]

The FDA banned the remedy in 1993 and urged other countries to do the same. In South Africa, it had already become popular among Xhosa-speaking sangomas (or “diviners”), who used Drittewelle’s product instead of their own increasingly scarce traditional plant medicines. Specifically for them, the drug was repackaged and distributed as Ubulawu Nomathotholo : “Medicine of the Singing Ancestors.” [30] [42]

Between 1994 and 1995, 2C-B was added to Schedule I of the Controlled Substances Act in the United States. [27] [43] South Africa and others followed with legislation of their own. In response, numerous research chemical analogs, such as βk-2C-B, were developed to circumvent the law. [44]

Current usage

According to the 2014 Global Drug Survey (of a limited sample of self-selected respondents who use psychoactive drugs), 2C-B ranks among the top 20 substances used in the past year in nine different countries. The highest prevalence was in the UK, the Republic of Ireland, and the Netherlands. [45]

2C-B also appears to be one of the most commonly sourced substances on the darknet. [46] [47] [48]

“2C-B is a cheap MDMA substitute”

Although 2C-B has sometimes been sold as MDMA, the effects are substantially different. Also, 2C-B doesn’t tend to be much cheaper. [4] In the United States, it can reach similar prices to MDMA and sometimes even more. [49]

“2C-B causes violent aggression”

Can it be detected in a drug test.

2C-B cannot be detected in either standard or extended drug tests. While it could potentially trigger a false positive for amphetamines, this is unlikely given the small doses involved. [52]

The detection of 2C-B usually requires technical analysis by a specialist lab using GC/MS (gas chromatography mass spectrometry) or LC-MS (liquid chromatography-mass spectrometry). [53] [54] [55] [56]

Can I test my 2C-B to see if it’s safe to take?

Testing your 2C-B is always good practice even when you trust your supplier. Reagent test kits from Bunk Police can identify hundreds of adulterants and substitutes —offering peace of mind and potentially saving your life.

The Mecke and Froehde reagents, for example, can help identify real 2C-B. Simply place a tiny amount of 2C-B into a sterile test tube or onto a sterile white ceramic surface and add a few drops of the reagent. 2C-B is the only drug known to turn this reagent a bright greenish-yellow color. [27] [28]

Can 2C-B cause psychological trauma?

Despairing thoughts, paranoid delusions, and frightening visuals (like facial distortions) may occur during a 2C-B trip. [57] [58] At very high doses, some have questioned their sanity. [59] One user even reported an alarming fear of anything alive—even plants. [7]

Nevertheless, the few cases of long-term psychosis attributed to 2C-B are highly questionable, and it’s not known that the drug was even involved.

To minimize negative experiences on 2C-B, always keep in mind the 6Ss of psychedelic use and prepare appropriately.

Are there risks?

2C-B affects the heart rate, blood pressure, and the central nervous system, which could make it unsafe for people with convulsive seizure disorders (e.g. epilepsy), heart problems, diabetes, schizophrenia, or a history of mental illness. See the Benefits & Risks section above for more information.

What is the best way to take 2C-B?

The most common way to take 2C-B is also the easiest: swallowing it as a liquid, tablet, or capsule. Other methods include snorting, vaporizing, and “plugging” (rectal administration).

Snorting 2C-B is almost unbearably painful because of its insolubility in water. However, the effects tend to be more intense, with a shorter onset, and a much smaller required dose. Shulgin suggested snorting the more water-soluble acetate or hydrobromide salt for the same effects with little to no pain. [3]

Vaporizing freebase 2C-B in a glass pipe is reportedly more potent and faster-acting than oral use, but with a shorter total duration. [60] “Plugging” liquid 2C-B into the rectum with a needleless syringe has similar effects, even on a full stomach. [61] [62]

Can I microdose with 2C-B?

Users who microdose with 2C-B have had mixed results, with some casual experimenters getting nothing out of the experience. [63] Others have reported crisper vision, enhanced tactile awareness, and a mental energy boost comparable to caffeine. [64] [65]

At this time, it’s unclear whether it’s worthwhile to microdose with 2C-B.

Does it produce tolerance?

Most but not all users report a tolerance effect from regular use (more than once every five to seven days). Since 2C-B doesn’t tend to be habit-forming, this isn’t usually a problem.

Can I mix it with other drugs?

Shulgin’s recommendation was to take it at the tail-end of an MDMA trip. Others have found it combines well with ketamine, making it easier to move without nausea and improving recollection of the K-hole. [10]

There are some drugs that 2C-B should not be mixed with, however. It is potentially very dangerous in combination with MAOIs, tramadol, mescaline, amphetamines, cocaine, and others.

[1] Center for Cognitive Liberty & Ethics. Dr. Alexander Shulgin – What is 2C-B? What are its effects? Retrieved from: http://www.cognitiveliberty.org/ccle1/shulgin/adsarchive/2cb.htm

[2] Erowid. (1996). 2C-B Dose. Retrieved from https://erowid.org/chemicals/2cb/2cb_dose.shtml .

[3] Spoerke, D. G. (1999, March 19). 2C-B FAQ. Retrieved from https://erowid.org/chemicals/2cb/2cb_faq.shtml .

[4] Erowid. (2000, Aug 21). 2C-B Basics. Retrieved from https://www.erowid.org/chemicals/2cb/2cb_basics.shtml .

[5] Shulgin, A. T., Carter, M. F. (1975). Centrally Active Phenethylamines. Psychopharmacology Communications, 1(1), 93-98.

[6] PsychonautWiki. 2C-B. Retrieved from https://psychonautwiki.org/wiki/2C-B .

[7] Shulgin, A., Shulgin, A. (1995). PiHKAL: A Chemical Love Story. Berkeley, CA: Transform Press.

[8] Erowid. (1998). 2C-B Effects. Retrieved from https://www.erowid.org/chemicals/2cb/2cb_effects.shtml .

[9] phenothiazine. (2009, Feb 1). Alexander Shulgin @ Psychedelic and Spirituality Conference 1983 (3/3) [Video]. Retrieved from https://www.youtube.com/watch?v=8kuMZ3FcB6I .

[10] Turner, D. M. (1994). The Essential Psychedelic Guide. San Francisco, CA: Panther Press.

[11] Gracie and Zarkov. (1984). A High Dose 2C-B Trip. Retrieved from https://erowid.org/chemicals/2cb/2cb_info2.shtml .

[12] Shulgin, A. (2003, Feb 7). Ask Dr. Shulgin Online: 2,5-dimethoxy-4-bromophenethylamine. Retrieved from http://www.cognitiveliberty.org/shulgin/adsarchive/2cb.htm .

[13] phenothiazine. (2009, Feb 1). Alexander Shulgin @ Psychedelic and Spirituality Conference 1983 (1/3) [Video]. Retrieved from https://www.youtube.com/watch?v=TaBMy63VGDw .

[14] Dean, B. V., Stellpflug, S. J., Burnett, A. M., Engebretsen, K. M. (2013). 2C or Not 2C: Phenethylamine Designer Drug Review. Journal of Medical Toxicology, 9(2), 172-178.

[15] Nichols, D. E. (2004). Hallucinogens. Pharmacology & Therapeutics, 101(2), 131-81.

[16] Villalobos, C. A., Bull, P., Sáez, P., Cassels, B. K., Huidobro-Toro, J. P. (2004). 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes. British Journal of Pharmacology, 141(7), 1167-1174.

[17] Moya, P. R. et al. (2007). Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors. The Journal of Pharmacology and Experimental Therapeutics, 321(3), 1054-1061.

[18] Rickli, A., Luethi, D., Reinisch, J., Buchy, D., Hoener, M. C., Liechti, M. E. (2015). Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs). Neuropharmacology, 99, 546-53.

[19] González, D., Torrens, M., Farré, M. (2015, Aug 7). Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions. Retrieved from https://erowid.org/references/texts/show/8836docid7724 .

[20] Theobald, D. S., Maurer, H. H. (2007). Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochemical Pharmacology, 73(2), 287-97.

[21] Nugteren-van Lonkhuyzen, J. J., van Riel, A. J., Brunt, T. M., Hondebrink, L. (2015). Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans. Drug and Alcohol Dependence, 157, 18-27.

[22] orangefairy. (2009, Jan 13). 2CB OVERDOSE: An Experience with 2C-B (ID 71809). Retrieved from https://www.erowid.org/experiences/exp.php?ID=71809 .

[23] The Flow. (2005, Jan 21). Anyone experience on high-dose 2C-B [Msg 1]. Message posted to https://www.hipforums.com/forum/topic/58938-anyone-experience-on-high-dose-2c-b/ .

[24] Ambrose, J. B., Bennett, H. D., Lee, H. S., Josephson, S. A. (2010). Cerebral vasculopathy after 4-bromo-2,5-dimethoxyphenethylamine ingestion. The Neurologist, 16(3), 199-202.

[25] Huang, H. H., Bai, Y. M. (2010). Persistent psychosis after ingestion of a single tablet of ‘2C-B’. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(1), 293-4.

[26] O’Loughlin, C. (2017). The harsh reality of the 2C-B drug. Retrieved from https://www.thecollegeview.com/2017/02/08/harsh-reality-2cb-drug/ .

[27] National Drug Intelligence Center. (2001). 2C-B (Nexus) Reappears on the Club Drug Scene. Information Bulletin, May 2001.

[28] Psychonautika. (2016, May 11). The Most Wonderful Introduction: An Experience with 2C-B (ID 108414). Retrieved from https://erowid.org/experiences/exp.php?ID=108414 .

[29] Eisner, B. (1993). Ecstasy: The MDMA Story. Berkeley, CA: Ronin Publishing.

[30] Anu. (1996, Feb). The Nexus Factor: An Introduction to 2C-B. Retrieved from https://erowid.org/chemicals/2cb/2cb_article1.shtml .

[31] Benson, T. (2015, Jul 15). All ‘Smiles’: the history of the 2C designer drug class. Retrieved from https://www.theverge.com/2015/7/15/8962743/all-smiles-the-history-of-the-2c-designer-drug-class .

[32] Páleníček, T. et al. (2013). Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats. Psychopharmacology, 225, 75-93.

[33] David. (2015, Oct 8). Solo Therapy, Introspective Empathogen: An Experience with 2C-B (ID 107035). Retrieved from https://erowid.org/experiences/exp.php?ID=107035 .

[34] jhleto. (2001, Mar 24). 2C-B Impressions: An Experience with 2C-B (ID 5851). Retrieved from https://www.erowid.org/experiences/exp.php?ID=5851 .

[35] AllyCat. (2008, Sep 30). A Life Changing View of Reality: An Experience with 2C-B (ID 70661). Retrieved from https://www.erowid.org/experiences/exp.php?ID=70661 .

[36] Zeke Ralston. (2011, Aug 12). Standing in the Light: An Experience with 2-CB (ID 92173). Retrieved from https://www.erowid.org/experiences/exp.php?ID=92173 .

[37] Susan. (1994). A Mother’s Report: 2-CB, from the Newsletter of the Multidisciplinary Association for Psychedelic Studies. Retrieved from http://www.maps.org/news-letters/v04n4/04457fam.html .

[38] International Narcotics Control Board. (2016). Green List, 27th edition. Retrieved from https://www.incb.org/documents/Psychotropics/greenlist/2016/V1604744_Eng.pdf .

[39] King, L. (2014). New phenethylamines in Europe. Drug Testing and Analysis, 6, 808-818.

[40] DEA 21 CFR Part 1308: Schedules of Controlled Substances; Temporary Placement of 4-Bromo-2,5-Dimethoxyphenethylamine Into Schedule I, 58 Fed. Reg. 58819 (October 29, 1993).

[41] Pachico, E. (2012, Nov 1). 2C-B Now Drug of Choice for Colombia Elite. Retrieved from http://www.insightcrime.org/news-analysis/2c-b-now-drug-of-choice-for-colombia-elite .

[42] TAC Ethnobotanical Database. History of Nexus. Retrieved from http://www.tacethno.com/info/2cb/2cbhistory.html .

[43] DEA 21 CFR Part 1308: Schedules of Controlled Substances; Placement of 4-Bromo-2,5-Dimethoxyphenethylamine Into Schedule I, 60 Fed. Reg. 28717 (May 25, 1995).

[44] Kroll, D. (2012, Oct 3). NBOMics: The Science of “Smiles”. Retrieved from http://blogs.plos.org/takeasdirected/2012/10/03/nbomics-the-science-of-smiles/ .

[45] Global Drug Survey 2014. Last 12 Month Prevalence of Top 20 Drugs.

[46] Van Hout, M. C., Bingham, T. (2013). ‘Surfing the Silk Road’: a study of users’ experiences. The International Journal on Drug Policy, 24(6), 524-9.

[47] Winstock, A. R. (2015). The Global Drug Survey 2015 findings. Retrieved from https://www.globaldrugsurvey.com/the-global-drug-survey-2015-findings/ .

[48] Global Drug Survey (2016). The Global Drug Survey 2016 findings. Retrieved from https://www.globaldrugsurvey.com/past-findings/the-global-drug-survey-2016-findings/ .

[49] Street Price 2cb [Reddit]. Retrieved from https://www.reddit.com/r/2cb/comments/55awsv/street_price_2cb/ .

[50] Sales, D., Heighton, L. (2013, Jan 27). ‘Exorcist’ danger drug 2CB just a click away on net. Retrieved from https://www.thesun.co.uk/archives/news/449068/exorcist-danger-drug-2cb-just-a-click-away-on-net/ .

[51] Clarke, N. (2013, Jan 28). The ecstasy recipe book that’s killing young people like Charlotte – and turning others into raging monsters. Retrieved from http://www.dailymail.co.uk/news/article-2269308/The-ecstasy-recipe-book-thats-killing-young-people-like-Charlotte–turning-raging-monsters.html .

[52] Erowid. (2015). 2C-B Drug Testing. Retrieved from https://erowid.org/chemicals/2cb/2cb_testing.shtml .

[53] Vorce, S. P., Sklerov, J. H. (2004). A general screening and confirmation approach to the analysis of designer tryptamines and phenethylamines in blood and urine using GC-EI-MS and HPLC-electrospray-MS. Journal of Analytical Toxicology, 28(6), 407-10.

[54] Theobold, D. S., Fritschi, G., Maurer, H. H. (2007). Studies on the toxicological detection of the designer drug 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B) in rat urine using gas chromatography-mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 846(1-2), 374-7.

[55] Pichini, S. et al. (2008). Liquid chromatography-atmospheric pressure ionization electrospray mass spectrometry determination of “hallucinogenic designer drugs” in urine of consumers. Journal of Pharmaceutical and Biomedical Analysis, 47(2), 335-42.

[56] Kerrigan, S., Banuelos, S., Perrella, L., Hardy, B. (2011). Simultaneous Detection of Ten Psychedelic Phenethylamines in Urine by Gas Chromatography-Mass Spectrometry. Journal of Analytical Toxicology, 35(7), 459-469.

[57] Doctor. (2012, Jun 25). Worthless Anxious Confusion: An Experience with 2C-B (ID 96517). Retrieved from https://www.erowid.org/experiences/exp.php?ID=96517 .

[58] RobertJohnson35. (2016, May 18). Humdinger Terror: An Experience with 2C-B (ID 107333). Retrieved from https://www.erowid.org/experiences/exp.php?ID=107333 .

[59] Tryed-It. (2008, Aug 15). Heart Matrix – Overload: An Experience with 2C-B (ID 71783). Retrieved from https://www.erowid.org/experiences/exp.php?ID=71783 .

[60] Vaporizing 2C-B? [Reddit]. Retrieved from https://www.reddit.com/r/Drugs/comments/17bdq8/vaporizing_2cb/ .

[61] xnidcx. (2007, Sep 6). B’s Best in the Butt: An Experience with 2C-B (ID 60582). Retrieved from https://erowid.org/experiences/exp.php?ID=60582 .

[62] My experience with 2C-B plugging (rectal administration) [Reddit]. Retrieved from https://www.reddit.com/r/Drugs/comments/35zggi/my_experience_with_2cb_plugging_rectal/ .

[63] Thomas, S. (2016, Dec 13). My Year in Productivity While Microdosing. Retrieved from https://www.vice.com/en_uk/article/my-year-in-productivity-while-microdosing .

[64] Microdosing 2c-b [Reddit]. Retrieved from https://www.reddit.com/r/Drugs/comments/39i6li/microdosing_2cb/ .

[65] Microdosing? [Reddit]. Retrieved from https://www.reddit.com/r/2cb/comments/51is60/microdosing/ .

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What is 2C-B?

In This Article

Little is known about the drug 2C-B. However, a recent resurgence in today’s nightlife culture is bringing back cause for alarm.

Although popular for its recreational effects, 2C-B use can lead to addiction and other long-term consequences. In this article, we cover 2C-B’s effects, health risks, and the proper response during a potential bad trip or overdose.

2C-B is a novel psychoactive drug that alters a person’s thought process, sense of time, and emotions. It causes euphoria and stimulating feelings.

2C-B is a 2C drug, part of a group called phenethylamines. That makes it a psychedelic that causes stimulant effects.

Anecdotal reports claim that the drug typically appears as a white powder or crystal. It’s also available in tablet form, similar to MDMA.

2C-B is also known by slang terms, which include:

• Blue Mystic

Most people take 2C-B orally and experience a burning sensation when ingesting the drug. Occasionally, people snort it, though doing so often causes nosebleeds and is potentially lethal. Some insufflate or vaporize the substance, though this is rare.

What Is the History of 2C-B?

2C-B was first synthesized in 1974 as a therapy aid. A 2015 study in Spain suggested that the drug reduced aggression and encouraged open-mindedness, but the results were inconclusive.

When MDMA was outlawed in 1985, 2C-B became the street drug of choice for its euphoric and psychedelic effects. Studies show that most people who use these drugs are young adults who frequently attend raves.

Is 2C-B Legal?

2C-B is a Schedule I drug with no accepted medical drug use and a high potential for addiction. As a Class A drug, it’s illegal to buy, possess, and sell. Possession of 2C-B is punishable by up to 7 years in prison, a fine, or both.

2C-B is most commonly distributed on the dark web. According to the 2019 Global Drug Survey, darknet purchases of the drug significantly increased over 5 years, along with other drugs like DMT and ketamine.

Sellers often attempt to pass the drug off as MDMA, with a street price of $10 to $30 per tablet, while a gram of the drug costs between $200 and $500.

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Effects of 2C-B

2C-B Is a psychedelic drug typically producing euphoric effects. Below is a comprehensive look at its acute pharmacological effects.

What Are the Short-Term Effects of 2C-B?

Snorting 2C-B is often painful, causing a burning sensation in the nostrils. Its effects kick in after half an hour has passed, which include the following:

• Anticipation (feeling apprehensive or easily distracted)

Many people also feel sexual arousal, coupled with symptoms like:

• Raised hairs
• Dilated pupils
• Muscle spasms

Because the beginning of the high is painful, most people report having an unpleasant experience with the drug.

How Does 2C-B Affect Mood and Perception?

Because 2C-B is also a psychedelic drug, its acute effects include hallucinations. People may experience the following:

• Facial distortions
• Moving surfaces
• Enhanced or shifting colors
• “Seeing” sounds

Many describe its effects as similar to a cross between MDMA and LSD.

Other effects include feeling extremely sociable, though it may be difficult to converse with another person. Some report feeling happy and in tune with their surroundings, experiencing introspective thoughts and increased empathy.

Taking higher doses can further cause negative effects, which include the following:

• Claustrophobia
• Muscle clenching
• Severe psychosis
• Intense hallucinations
• Nausea and vomiting
• Increased blood pressure

How Does 2C-B Impact Mental Health?

People diagnosed with a mental illness are more significantly at risk of its adverse effects. Because 2C-B induces psychedelic sensations, many people with an existing mental illness have a greater chance of getting an unpleasant experience. 

Some mental effects of 2C-B include:

• Confusion and agitation
• Tiredness and fatigue
• Inability to concentrate or, adversely, hyper fixation

What Are the Long-Term Effects of 2C-B Use?

While hallucinogens are not typically addictive, 2C-B’s stimulant effects can lead to addiction, causing long-term negative effects. People may depend on the drug to achieve positive feelings, neglecting aspects of their daily lives to acquire or use it.

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How Long Do 2C-B Effects Last?

Anecdotal reports claim the “come-down” period of 2C-B typically lasts between 2 and 4 hours. During this comedown, some people may experience a bad trip, causing them to “crash” or become depressed.

How long it takes for someone to come down from these drugs ultimately depends on the dosage, how frequently a person uses a drug, their weight and metabolism, and whether they use other drugs simultaneously.

What Are the Potential Risks of Taking 2C-B?

Because 2C-B is illegal and produced in secret laboratories, these illicit drugs are often laced with other substances, causing significant physical and mental risks. In addition, the amount in a single capsule or tablet can vary significantly.

Common adverse reactions to 2C-B include:

• Panic attacks
• Delirious states
• High risk of over-stimulating the heart, leading to cardiac arrest.

Mixing 2C-B with other drugs can be unpredictable and potentially life-threatening.

When mixing 2C-B with other psychedelics like cannabis, a person might experience anxiety and increase the probability of a bad trip. Mixing 2C-B with tramadol, in particular, can cause seizures.

Are There Any Therapeutic Uses of 2C-B?

There currently are no proven therapeutic uses of the drug. When it was first used within the psychiatric community, 2C-B was sold as a sexual enhancer.

Can You Overdose on 2C-B?

There is currently no known fatal dose of 2C-B. However, taking it with other drugs can significantly increase the risk of overdose.

2C-B’s anesthetizing effects can also cause severe injuries to go unnoticed, discouraging people from seeking medical attention.

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How Can You Recognize Signs of 2C-B Use?

It may be challenging to identify if someone has used 2C-B. The simplest way to recognize signs of use is through observational study. Knowing the side effects caused by 2C-B is imperative, as it has no recorded withdrawal symptoms.

What to Do During a Bad Trip or Overdose

When experiencing a bad trip or overdose, seek medical attention immediately. If possible, have someone monitor your symptoms until help arrives.

Alternatively, you may have a spirit guide or trip sitter—someone who remains sober and monitors your well-being throughout the experience.

How Do I Stop Using 2C-B?

Like with most psychedelic drugs, quitting 2C-B cold turkey can be challenging. Most experienced users recommend reducing dosages to wean off the drug. When stopping 2C-B use, using a milligram scale to weigh the dosage is best.

2C-B is a stimulant and hallucinogen and can negatively impact one’s physical health and well-being. People often take it with other psychedelic drugs, increasing the probability of addiction and even death.

If you or someone you know is demonstrating signs of drug addiction, seek treatment immediately.

What's Next?

• What Is Rehab Like?
• Why Call an Addiction Hotline?
• How to Sober Up
• Tapering off of alcohol

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• Nugteren–van Lonkhuyzen et al. “Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans.” Drug and Alcohol Dependence, ScienceDirect, 2015.
• Papaseit et al. “Acute Pharmacological Effects of 2C-B in Humans: An Observational Study.” Frontiers in Pharmacology, 2018.
• Yanakieva et al. “Acquired synaesthesia following 2C-B use.” Psychopharmacology, Springer Link, 2019.
• González et al. “Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions.” BioMed Research International, 2015.
• Mallaroni et al. “Assessment of the Acute Effects of 2C‐B vs. Psilocybin on Subjective Experience, Mood, and Cognition.” Clinical Pharmacology & Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2023.

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Evidence Based

Who answers.

Can a “bad” psychedelic trip be exactly what you “need”? 

Here’s why:.

In the context of psychedelic therapy, a “bad trip” refers to a challenging or difficult experience during a psychedelic session. While bad trips can be distressing, they are not necessarily negative or counterproductive to the therapeutic process. In fact, they can often be an integral part of the healing journey.

Challenging experiences, such as a bad trip, can bring unresolved issues, traumas, or emotions to the surface. By confronting these difficult aspects of oneself, individuals can work through and facilitate deep healing and transformation.

Bad trips can provide valuable insights into one’s subconscious mind, thought patterns, and emotional wounds. Through careful reflection and integration, individuals can gain a deeper understanding of themselves and their inner struggles, leading to greater self-awareness and personal growth.

Sometimes, a bad trip can be cathartic, allowing individuals to release pent-up emotions, fears, or traumas in a safe and supportive environment. This emotional release can be therapeutic and transformative, helping individuals to let go of past pain and move forward with greater emotional freedom and resilience.

Psychedelic therapy sessions are typically followed by integration sessions, where individuals work with therapists to make sense of their experiences and integrate the insights gained into their daily lives. These integration sessions provide crucial support for individuals navigating difficult or challenging experiences, helping them to process their emotions, gain perspective, and develop coping strategies.

Even challenging experiences can offer valuable lessons and opportunities for personal growth. By facing and overcoming adversity during a bad trip, individuals can develop resilience, strength, and a deeper sense of self-understanding. These lessons can be carried forward into other areas of life, leading to positive changes and personal development.

It’s important to note that while bad trips can have therapeutic benefits, they should always be approached with caution and under the guidance of trained professionals in a safe and supportive environment. Proper preparation, set, and setting are essential for minimizing the risk of adverse reactions and maximizing the therapeutic potential of psychedelic therapy. Additionally, individuals should have access to ongoing support and integration resources to help them navigate challenging experiences and integrate their insights into their lives effectively.

If you are interested in learning more  reach out for a free consultation with one of our Ko-Op clinicians.

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Appointment Request

LICENSED PROFESSIONAL COUNSELOR LPC,MHS, LCADC

I am a Licensed Professional Counselor (LPC) with over twenty five years experience in the behavior health field who believes that psychedelic assisted therapies and support have the potential to support people with integrating their lived experiences to become whole again. Being able to have meaningful experiences while being supported with other therapies such as EMDR therapy or internal family systems (IFS) can lead to finding the safety and compassion needed to heal the hurt and burdened parts of yourself.

I can work with you first to identify the parts of you that need healing, their origin, and the role(s) they play in your life. Then I can support and guide you through that process to help you find a more integrated space in your life and body.

Dr. Christopher Deussing

Licensed clinical social worker (lcsw) doctor of social work (dsw).

I’m a clinician who strongly believes in the power of psychedelic-assisted psychotherapy to heal the mind, body, & spirit. I’ve seen these medicines help many clients.

Currently, I focus on using Ketamine-Assisted Psychotherapy (KAP), which can catalyze the discovery of deep emotions, thoughts, & experiences. KAP sessions can create profound opportunities for growth. Sometimes KAP is like compressing years of therapy in just a few hours.

I want to create an individualized plan that works for you, so let’s discuss your hopes, wants, & needs. A psychedelic experience is very personal, & I’m here to help you explore what’s possible with KAP.

Arnold B. Meshkov MD

Medical provider.

Arnold B. Meshkov MD is a Fellow of the American College of Cardiology and board certified in Internal Medicine.  He is a former Professor of Medicine at Temple University School of Medicine in Philadelphia, and trained at the University of Pennsylvania, Temple University, and Yale University. He has extensive experience and expertise in the assessment of patients prior to surgical procedures and new medication.  Dr. Meshkov has practiced at Temple University School of Medicine as a academic, and also has many years of experience in the private practice of Internal Medicine and Cardiology   He is a former Professor of Medicine at Temple University School of Medicine in Philadelphia, and trained at the University of Pennsylvania, Temple University, and Yale University. He has extensive experience and expertise in the assessment of patients prior to surgical procedures and new medication .  Dr. Meshkov has practiced at Temple University School of Medicine as a academic, and also has many years of experience in the private practice of Internal Medicine and Cardiology  

Gwenn Prinbeck

Clinical social work/therapist, lsw, pcc.

Psychedelic-assisted psychotherapy can be a powerful tool for promoting openness and connections, especiallyfor those feeling stuck or adrift.The medicine can offer a liminal space forself-exploration, emergence, and discovery. The experiences had there can have profound and lasting impacts.

My aim as the therapist in the psychedelic space is to create a safe and supportive environmentin which your unique experience with the medicinecanunfold. I work with you throughout each step of the process and see no part as being more important than another. Before working with the medicine, our goal is to establish an attuned relationship with one anotherand to clarify the intentions for journeying. After each medicine session, we will consider the experience and look for ways to integrate what’s emerged into the rest of your life.

A contemplative and compassionate relationship with the self is a healthy fundamental instinct, but this instinct can be hampered by adverse and traumatic experiences. What’s more, when we struggle to be OK with ourselves, we often struggle relating to others. I offer support healing emotional wounds and constructing deeper and lasting connections with the self and others.

I work with adult individuals and children who are 10 years or older, I also offer family and couples therapy. I aim to be welcoming and mindful of the myriad social injustices impacting so many of us. In addition to what’s often called talk therapy, I work with experiential modalities that engage in creative, mindful, and somatic ways to help us access inherent wisdom that can lie beyond ordinary talking. I hope to help you build robust skills that ease the challenges that come with fostering acceptance and change.

I began my studies and career in science and then for almost a decade, I offered support as a certified professional life coach before attending Bryn Mawr College’s School of Social Work and Social Research to broaden my ability to support people’s resilience and potential. I am additionally trained in family systems work and provide ketamine-assisted psychotherapy.

LICENSED SOCIAL WORKER (LSW)

Psychedelic assisted psychotherapy is a modality that is particularly good at helping develop our awareness by allowing us to encounter ourselves and our experiences in unique and poignant ways. Inviting and working with expanded consciousness in therapy often begets sessions full of rich content, permitting a more authentic self to emerge in therapy and beyond. As a psychotherapist whose practice is rooted in psychodynamic and relational theories, I’m attentive to how past experiences inform present circumstances, and this helps me provide attuned support throughout the ordinary and extraordinary experiences of psychedelic assisted psychotherapy.

I appreciate helping people through transitions such as navigating grief and loss, adjusting to major life changes, and addressing shifts in motivation and focus. I have extensive experience supporting people who are tackling addiction and recovery, either for themselves or within their families and communities. For many, compulsive behavior, or addiction, begins as a way of enduring but over time the behavior can end up inhibiting our ability to relate to others and ourselves. I offer a place to build resilience and rediscover the self.

Jennifer O’Donnell

M.a., counseling psychology, certified psychedelic facilitator through soundmind in phila..

Jennifer is an experienced mindfulness-based psychotherapist. She holds a Master’s degree from Delaware Valley University in Counseling Psychology, and a Bachelor of Arts degree in Political Science from Temple University. Jennifer is a certified sexual assault counselor, an experienced certified yoga therapist, and a certified yoga and Pilates instructor. Jennifer has completed post graduate training with Soundmind Institute in Philadelphia as a certified Psychedelic Facilitator. She offers an array of therapeutic techniques which include: Trauma Focused – Cognitive Behavioral Therapy (TF-CBT), Dialectical Behavior Therapy (DBT), Mindfulness Based Stress Reduction strategies and trauma informed yoga therapy. Jennifer’s therapeutic approach encompasses the integration of therapy, yoga, breath work and mindfulness and includes a blend of therapeutic modalities such as somatic experiencing, attachment theory, psychodynamic, and Hakomi.

“ I see counseling as a safe and therapeutic relationship. My approach is a blend of both clinical and alternative therapies designed to meet the needs of each individual. The goal is for you to gain insight and clarity into your thoughts and feelings in a supportive and encouraging relationship as we uncover new paths to your personal healing and transformation. I believe we all carry inner wisdom, and when we start quieting our minds and listening to our bodies the wisdom can then be heard.” Jennifer has experience in treating trauma, PTSD, anxiety, depression, bipolar disorder, obsessive compulsive disorder, women’s issues, family conflict, sexual and gender identity issues, grief, behavioral issues and life transitions. Jennifer has a deep understanding of how trauma shows up in the body, and continues her personal practices to deepen her own understanding of self, consciousness, and collective healing.

Sophia Polin

Licensed professional counselor (lpc).

I am an integrative therapist whose practice combines relational theory with elements of Cognitive Behavioral Therapy. In my standard practice I work with adults and adolescents with histories of trauma, who are facing major life transitions, struggling with anxiety and depression, who are dealing with relationship discord, or who want to explore their full potential. I have substantial experience working with Post-Traumatic Stress Disorder as well as Obsessive Compulsive Disorder. I practice Exposure and Response Prevention (E/RP) for OCD, and take expert care in helping my clients face and overcome what they fear most.

In session, I emphasize attuning to the mind-body connection, habituating to feelings of vulnerability, and integrating disparate “parts” of the psyche in order to guide clients towards conscious, intentional lives and relationships. I consider early life and relationships to be integral in the formation of the personality and of patterns of behavior later in life.

I have recently expanded my practice to include psychedelic therapy. The use of psychedelics in a therapeutic setting gives clients the unique opportunity to distance from ingrained ways of thinking, connect with their own healing intuition, and dissolve the boundaries of self that are no longer serving them. The transformative shifts we are seeing in Ketamine treatments are the result of— the creation and reorganization of pathways in the brain (neurogenesis and neuroplasticity). These are the same processes therapists have been using traditionally to support their client’s growth and healing. I like to think of it as automating what has traditionally only been achievable manually.

Occupying altered states can be scary at first. My role as a psychedelic therapist is to lay the grounds for a safe and revelatory journey. In our preparation sessions we will build essential trust, explore your history, and collaboratively set your intention for your psychedelic experience. We will use our integration sessions post- treatments to synthesize and apply the wisdom gleaned from your journey to affect lasting, meaningful change. Whether you are experienced with psychedelics or exploring psychedelia for the first time, I am with you every step of the way.

Stephanie Josephson

Dr. Sophia Brandstetter

Lcsw, psyd clinical director.

I am a licensed psychotherapist who is rooted in psychoanalysis and psychodynamic and relational theories. In recent years, as a compliment to my psychotherapeutic approaches, I’ve shifted my training to include psychedelic medicines as a method for integrating the mind, body, and soul. In many ways we are rediscovering verifiable facts about the impact of psychedelic medicines on our neurochemistry, physiology, and psychology. I have witnessed plant medicine as a power catalyst for change for my patients.

At this time our work must center around Ketamine Assisted Psychotherapy. Ketamine is renowned for uncovering our intrinsic healing capacity while transporting us to a place of  higher consciousness . The ketamine psychotherapy experience can bring attention to deep-rooted emotions, patterns, narratives, and/or experiences that could be unconscious sticking points or barriers to our growth. Ketamine sessions often access an abundance of material that might take months or years to uncover in traditional psychotherapy. Previous patients have stated,  I have felt in a couple of hours, I have learned more about myself than I have in several years of psychoanalysis.  Confirmations like this are common and the insight the ketamine sessions impart can remain long after the effects of the ketamine have dissipated.

At higher dosages, psychedelic medicines have the capacity to allow for significant disruptions of self‑consciousness, a phenomenon known as medicine-induced ego dissolution. Using your experience with the medicine as a guide, we can collaborate in understanding the experience of dissolution to create opportunities for regeneration and integration.

As you can see, I believe providing therapeutic support to be a vital part of the curative mechanism of the psychedelic experience. Together we will work on building a therapeutic relationship founded on trust, safety, and mutual respect for the sacred work the medicine can help facilitate. The approach we co-create can enhance the experience and make way for relief and change.

If you’re entering treatment to address trauma or if you’ve experienced trauma, it’s important to understand the healing significance of the therapist as a witness. Research on treating trauma explores how the witnessing (experiencing the presence of another) is considered an essential prerequisite for our capacity to narrate our experiences. One of the crucial impacts of a trauma is the damaging effect caused by the absence of a witness: without a witness we may have lost touch with how to make sense of what has happened, but when we gain a witness, the experience becomes more possible to know and understand, and healing can begin. As your witness in your psychedelic journey my role is to be visible in all the necessary ways to offer support.

My  intention is to design a program that meets your expectations. I’m open to the many possibilities of what may work for you and want to invite you to imagine and share your hopes and needs for the journey. A psychedelic experience is a personal process and I welcome the opportunity to meet for a free consultation to answer all your questions and provide you with a comprehensive understanding of the possibilities

No Preference

2C-P/Summary

Main article: 2C-P

Psychoactive class: Psychedelic

Chemical class: Substituted phenethylamines

• Total : 10 - 20 hours
• Onset : 1 - 3 hours
• Come up : 2 - 4 hours
• Peak : 4 - 8 hours
• Offset : 3 - 6 hours
• Afterglow : 8 - 48 hours

Harm potential

• Low potential for abuse and dependence
• Toxic dose is unknown
• Full tolerance is reached almost immediately after ingestion
• Decreases to half after 3 days
• Returns to baseline after 7 days
• Cross-tolerance with all psychedelics

Physical effects

• Bodily control enhancement
• Stimulation
• Increased blood pressure
• Increased bodily temperature
• Increased heart rate
• Teeth grinding
• Temperature regulation suppression

Visual effects

• Color enhancement
• Pattern recognition enhancement
• Visual acuity enhancement
• After images
• Auditory distortion
• Color shifting
• Depth perception distortions
• Scenery slicing
• Symmetrical texture repetition
• Time distortion
• Geometry : Eventually leads to level 8B geometry
• Autonomous entity
• Internal hallucination
• Perspective hallucination
• Settings, sceneries, and landscapes
• Transformations
• Unspeakable horrors

Cognitive effects

• Autonomous voice communication
• Conceptual thinking
• Multiple thought streams
• Thought loop
• Analysis enhancement
• Creativity enhancement
• Increased libido
• Increased music appreciation
• Novelty enhancement
• Memory suppression
• Personal bias suppression

Auditory effects

• Auditory acuity enhancement
• Auditory hallucination

Multi-sensory

• Machinescapes
• Scenarios and plots
• Responsible use
• Summary index
• Subjective effect index
• Psychoactive substance index

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